Danny Trejo

Machete Cortez

Mel Gibson

Luther Voz

Demián Bichir

Mendez

Amber Heard

Blanca Vasquez / Miss San Antonio

Michelle Rodriguez

Luz

Sofía Vergara

Desdemona

Charlie Sheen

Mr. President (credited as Carlos Estévez)

Jessica Alba

Sartana Rivera

Lady Gaga

La Camaleon

Alexa PenaVega

KillJoy

Vanessa Hudgens

Cereza Desdemona

Tom Savini

Osiris Amanpour

Cuba Gooding Jr.

El Camaleon

Antonio Banderas

El Camaleon

Walton Goggins

El Camaleon

William Sadler

Sheriff Doakes

Marko Zaror

Zaror

Julio Oscar Mechoso

Chepo

Billy Blair

Billy

Samuel Davis

Clebourne

Felix Sabates

Doc Felix

Electra Avellan

Nurse Mona

Elise Avellan

Nurse Lisa

Marci Madison

Nurse Fine

Callie Hernandez

Space Babe

Alejandro Antonio

Boss of Mendez

Crystal Martinez

Wife of Mendez

Corey Burton

Trailer Voice Guy (voice)

Elon Musk

Elon Musk

Emmy Robbin

Pris

Jason Christopher

Lieutenant Brass

Sam Medina

Cartel Leader

J.J. Perry

Voz's Henchman (uncredited)

Alexander Rodnyansky

Radio Guest (uncredited)

Vincent Fuentes

Cabrito Cook

Elle LaMont

Dollface

Jorge A. Jimenez

Dying Cartel Guy