Jake Gyllenhaal

Donnie Darko

Jena Malone

Gretchen Ross

James Duval

Frank

Drew Barrymore

Karen Pomeroy

Beth Grant

Kitty Farmer

Maggie Gyllenhaal

Elizabeth Darko

Mary McDonnell

Rose Darko

Holmes Osborne

Eddie Darko

Noah Wyle

Prof. Kenneth Monnitoff

Katharine Ross

Dr. Lilian Thurman

Patrick Swayze

Jim Cunningham

Daveigh Chase

Samantha Darko

Arthur Taxier

Dr. Fisher

David St. James

Bob Garland

Patience Cleveland

Roberta Sparrow / Grandma Death

Jazzie Mahannah

Joanie James

Jolene Purdy

Cherita Chen

David Moreland

Principal Cole

Kristina Malota

Susie Bates

Marina Malota

Emily Bates

Scotty Leavenworth

David

Phyllis Lyons

Anne Fisher

Gary Lundy

Sean Smith

Alex Greenwald

Seth Devlin

Stuart Stone

Ronald Fisher

Joan Blair

Mystery Woman

Seth Rogen

Ricky Danforth

Mark Hoffman

Police Officer

Jerry Trainor

Lanky Kid

Tom Tangen

Man in Red Jogging Suit

Carly Naples

Suzy Bailey

Lisa K. Wyatt

Linda Connie

Rachel Winfree

Shanda Riesman

Ashley French

Kim

Tiler Peck

Beth Farmer

Fran Kranz

Passenger

Sarah Hudson

Friend

Alison Jones

Dorky Half-Sister

Lee Weaver

Leroy

Jack Salvatore, Jr.

Larry Riesman

Nancy Fallon

Flight Attendant (uncredited)