Kara Kılıç Ustası olarak bilinen Guts, onu ve kadınını takip eden şeytani güçlerden korunacak bir sığınak ve onu kutsal olmayan bir kurban olarak damgalayan adamdan intikam alma yolları arar. Yardımcıları sadece muazzam gücü, yeteneği ve kılıcı olan Guts bir yandan insanlığını kaybettirecek bir öfkeyle savaşırkan bir yandan da kendi kasvetli kaderiyle mücadele eder. Berserk, Shakespeare?in Machbeth adlı eserinin temasıyla işlenmiş, zalim bir düellonun ve uğursuz bir kaderin, karanlık ve saplantılı hikayesidir.
Into a tavern walks a man with a massive sword, where he encounters a caged elf being bullied by grown men. Thus begins the strange partnership between the elf, Puck, and the swordsman, Guts.
Guts is still coming to terms with his fateful encounter with the monk and his daughter when he is confronted by the Holy Iron Chain Knights. Their commander berates him about his many sins is declares he is to be brought to the Holy See.
Guts and Puck are taken aback by Farnese's inability to see the elf. However, Farnese's refusal to accept anything beyond what she considers to be real in her world is about to be sorely tested.
Guts returns to a place he'd left two years ago to reconnect with old friends, but finds that someone he holds most dear has vanished. Guts tries to lay blame, but he is not entirely innocent.
Intent on finding Casca, Guts continues his journey toward the Tower of Conviction. Meanwhile, Farnese is already there, witnessing unspeakable horrors committed by those who serve the Holy See.
As Mozgus and his men continue their witchhunt for heretics, Farnese can't help but feel a twinge of doubt. Meanwhile, Guts unexpectedly encounters a familiar face, who brings ill tidings.
Guts is finally close to finding Casca, but Casca has caught the heretics' eye, and the Holy Iron Chain Knights are also homing in on the heretics' location...
Guts and crew venture into the Qliphoth to rescue the trapped villagers. Once inside, they're met with a parade of nightmares, and must fight for their lives against hideous creatures.
While Guts is suffering from his heavy injuries, the only hope to defeat his strong opponent is to equip the mysterious armor hidden in the Witch's house.
